3UPC
A general strategy for the generation of human antibody variable domains with increased aggregation resistance
Summary for 3UPC
Entry DOI | 10.2210/pdb3upc/pdb |
Related | 3UPA |
Descriptor | heavy chain variable domain, PENTAETHYLENE GLYCOL, TRIETHYLENE GLYCOL, ... (5 entities in total) |
Functional Keywords | immunoglobulin fold, immune system |
Biological source | Homo sapiens (human) |
Total number of polymer chains | 10 |
Total formula weight | 122428.96 |
Authors | Dudgeon, K.,Rouet, R.,Kokmeijer, I.,Langley, D.B.,Christ, D. (deposition date: 2011-11-17, release date: 2012-06-20, Last modification date: 2023-11-01) |
Primary citation | Dudgeon, K.,Rouet, R.,Kokmeijer, I.,Schofield, P.,Stolp, J.,Langley, D.,Stock, D.,Christ, D. General strategy for the generation of human antibody variable domains with increased aggregation resistance Proc.Natl.Acad.Sci.USA, 109:10879-10884, 2012 Cited by PubMed: 22745168DOI: 10.1073/pnas.1202866109 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.8 Å) |
Structure validation
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