3UN8

Yeast 20S proteasome in complex with PR-957 (epoxide)

Summary for 3UN8

Entry DOI	10.2210/pdb3un8/pdb
Related	1IRU 1PMA 1RYP 3UN4 3UNB 3UNE 3UNF 3UNH
Descriptor	Proteasome component Y7, Proteasome component C11, Proteasome component PRE2, ... (16 entities in total)
Functional Keywords	proteasome, antigen presentation, drug development, protein degradation, hydrolase-hydrolase inhibtior complex, hydrolase/hydrolase inhibtior
Biological source	Saccharomyces cerevisiae (Baker's yeast) More
Cellular location	Cytoplasm: P23639 P22141 P30656 P23724 P30657 P38624 P23638 P40303 P32379 P40302 P21242 P21243 P25043 P25451
Total number of polymer chains	28
Total formula weight	729038.59
Authors	Huber, E.,Basler, M.,Schwab, R.,Heinemeyer, W.,Kirk, C.,Groettrup, M.,Groll, M. (deposition date: 2011-11-15, release date: 2012-02-29, Last modification date: 2023-09-13)
Primary citation	Huber, E.M.,Basler, M.,Schwab, R.,Heinemeyer, W.,Kirk, C.J.,Groettrup, M.,Groll, M. Immuno- and constitutive proteasome crystal structures reveal differences in substrate and inhibitor specificity. Cell(Cambridge,Mass.), 148:727-738, 2012 Cited by PubMed: 22341445 DOI: 10.1016/j.cell.2011.12.030 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.7 Å)

Structure validation