3UN4

Yeast 20S proteasome in complex with PR-957 (morpholine)

Summary for 3UN4

• Entry DOI: 10.2210/pdb3un4/pdb
• Related: 1IRU 1PMA 1RYP 3UN8 3UNB 3UNE 3UNF 3UNH
• Related PRD ID: PRD_000991
• Descriptor: Proteasome component Y7, Proteasome component C11, Proteasome component PRE2, ... (16 entities in total)
• Functional Keywords: proteasome, antigen presentation, drug development, protein degradation, hydrolase -hydrolase-inhibitor complex, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• Biological source: Saccharomyces cerevisiae (Baker's yeast); More
• Cellular location: Cytoplasm: P23639 P22141 P30656 P23724 P30657 P38624 P23638 P40303 P32379 P40302 P21242 P21243 P25043 P25451
• Total number of polymer chains: 28
• Total formula weight: 732048.20

Authors

Huber, E.,Basler, M.,Schwab, R.,Heinemeyer, W.,Kirk, C.,Groettrup, M.,Groll, M. (deposition date: 2011-11-15, release date: 2012-02-29, Last modification date: 2023-09-13)

• Primary citation: Huber, E.M.,Basler, M.,Schwab, R.,Heinemeyer, W.,Kirk, C.J.,Groettrup, M.,Groll, M.; Immuno- and constitutive proteasome crystal structures reveal differences in substrate and inhibitor specificity.; Cell(Cambridge,Mass.), 148:727-738, 2012; PubMed: 22341445; DOI: 10.1016/j.cell.2011.12.030

Experimental method

X-RAY DIFFRACTION (3.4 Å)