3UEZ
Crystal structure of the human Colony-Stimulating Factor 1 (hCSF-1) cytokine in complex with the viral receptor BARF1
Summary for 3UEZ
Entry DOI | 10.2210/pdb3uez/pdb |
Related | 1HMC 2CH8 3UF2 3UF5 |
Descriptor | Secreted protein BARF1, Macrophage colony-stimulating factor 1, beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose (3 entities in total) |
Functional Keywords | viral receptor, rtkiii, extracellular, cytokine receptor-cytokine complex, cytokine, four-helix bundle, glycoprotein, immunoglobulin domain, oncogene, receptor, cytokine/signaling, protein complex, cytokine receptor/cytokine |
Biological source | Human herpesvirus 4 (HHV-4) More |
Total number of polymer chains | 8 |
Total formula weight | 167469.66 |
Authors | Elegheert, J.,Bracke, N.,Savvides, S.N. (deposition date: 2011-10-31, release date: 2012-08-22, Last modification date: 2020-07-29) |
Primary citation | Elegheert, J.,Bracke, N.,Pouliot, P.,Gutsche, I.,Shkumatov, A.V.,Tarbouriech, N.,Verstraete, K.,Bekaert, A.,Burmeister, W.P.,Svergun, D.I.,Lambrecht, B.N.,Vergauwen, B.,Savvides, S.N. Allosteric competitive inactivation of hematopoietic CSF-1 signaling by the viral decoy receptor BARF1 Nat.Struct.Mol.Biol., 19:938-947, 2012 Cited by PubMed: 22902366DOI: 10.1038/nsmb.2367 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (3.414 Å) |
Structure validation
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