3UEZ

Crystal structure of the human Colony-Stimulating Factor 1 (hCSF-1) cytokine in complex with the viral receptor BARF1

Summary for 3UEZ

• Entry DOI: 10.2210/pdb3uez/pdb
• Related: 1HMC 2CH8 3UF2 3UF5
• Descriptor: Secreted protein BARF1, Macrophage colony-stimulating factor 1, beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose (3 entities in total)
• Functional Keywords: viral receptor, rtkiii, extracellular, cytokine receptor-cytokine complex, cytokine, four-helix bundle, glycoprotein, immunoglobulin domain, oncogene, receptor, cytokine/signaling, protein complex, cytokine receptor/cytokine
• Biological source: Human herpesvirus 4 (HHV-4); More
• Total number of polymer chains: 8
• Total formula weight: 167469.66

Authors

Elegheert, J.,Bracke, N.,Savvides, S.N. (deposition date: 2011-10-31, release date: 2012-08-22, Last modification date: 2020-07-29)

• Primary citation: Elegheert, J.,Bracke, N.,Pouliot, P.,Gutsche, I.,Shkumatov, A.V.,Tarbouriech, N.,Verstraete, K.,Bekaert, A.,Burmeister, W.P.,Svergun, D.I.,Lambrecht, B.N.,Vergauwen, B.,Savvides, S.N.; Allosteric competitive inactivation of hematopoietic CSF-1 signaling by the viral decoy receptor BARF1; Nat.Struct.Mol.Biol., 19:938-947, 2012; PubMed: 22902366; DOI: 10.1038/nsmb.2367

Experimental method

X-RAY DIFFRACTION (3.414 Å)