3U8D
Functionally selective inhibition of Group IIA phospholipase A2 reveals a role for vimentin in regulating arachidonic acid metabolism
Summary for 3U8D
Entry DOI | 10.2210/pdb3u8d/pdb |
Related | 3U8B 3U8H 3U8I |
Descriptor | Phospholipase A2, membrane associated, (3-{[3-(2-amino-2-oxoethyl)-1-benzyl-2-ethyl-1H-indol-5-yl]oxy}propyl)phosphonic acid, CALCIUM ION, ... (5 entities in total) |
Functional Keywords | secreted phospholipase a2, phospholipase a2 activity, hydrolase |
Biological source | Homo sapiens (human) |
Total number of polymer chains | 2 |
Total formula weight | 29053.02 |
Authors | Lee, L.K.,Bryant, K.J.,Bouveret, R.,Lei, P.-W.,Duff, A.P.,Harrop, S.J.,Huang, E.P.,Harvey, R.P.,Gelb, M.H.,Gray, P.P.,Curmi, P.M.,Cunningham, A.M.,Church, W.B.,Scott, K.F. (deposition date: 2011-10-16, release date: 2012-10-17, Last modification date: 2019-07-17) |
Primary citation | Lee, L.K.,Bryant, K.J.,Bouveret, R.,Lei, P.W.,Duff, A.P.,Harrop, S.J.,Huang, E.P.,Harvey, R.P.,Gelb, M.H.,Gray, P.P.,Curmi, P.M.,Cunningham, A.M.,Church, W.B.,Scott, K.F. Selective Inhibition of Human Group IIA-secreted Phospholipase A2 (hGIIA) Signaling Reveals Arachidonic Acid Metabolism Is Associated with Colocalization of hGIIA to Vimentin in Rheumatoid Synoviocytes. J.Biol.Chem., 288:15269-15279, 2013 Cited by PubMed: 23482564DOI: 10.1074/jbc.M112.397893 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.805 Å) |
Structure validation
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