3U8I

Functionally selective inhibition of Group IIA phospholipase A2 reveals a role for vimentin in regulating arachidonic acid metabolism

Summary for 3U8I

• Entry DOI: 10.2210/pdb3u8i/pdb
• Related: 3U8B 3U8D 3U8H
• Descriptor: Phospholipase A2, membrane associated, CALCIUM ION, CHLORIDE ION, ... (5 entities in total)
• Functional Keywords: secreted phospholipase a2, hydrolase
• Biological source: Homo sapiens (human)
• Cellular location: Membrane; Peripheral membrane protein: P14555
• Total number of polymer chains: 2
• Total formula weight: 28676.15

Authors

Lee, L.K.,Bryant, K.J.,Bouveret, R.,Lei, P.-W.,Duff, A.P.,Harrop, S.J.,Huang, E.P.,Harvey, R.P.,Gelb, M.H.,Gray, P.P.,Curmi, P.M.,Cunningham, A.M.,Church, W.B.,Scott, K.F. (deposition date: 2011-10-17, release date: 2012-10-17, Last modification date: 2013-06-12)

• Primary citation: Lee, L.K.,Bryant, K.J.,Bouveret, R.,Lei, P.W.,Duff, A.P.,Harrop, S.J.,Huang, E.P.,Harvey, R.P.,Gelb, M.H.,Gray, P.P.,Curmi, P.M.,Cunningham, A.M.,Church, W.B.,Scott, K.F.; Selective Inhibition of Human Group IIA-secreted Phospholipase A2 (hGIIA) Signaling Reveals Arachidonic Acid Metabolism Is Associated with Colocalization of hGIIA to Vimentin in Rheumatoid Synoviocytes.; J.Biol.Chem., 288:15269-15279, 2013; PubMed: 23482564; DOI: 10.1074/jbc.M112.397893

Experimental method

X-RAY DIFFRACTION (1.1 Å)