3U0Y

Crystal structure of the Fucosylgalactoside alpha N-acetylgalactosaminyltransferase (GTA, cisAB mutant L266G, G268A) in complex with compound 382 and UDP

3U0Y の概要

• エントリーDOI: 10.2210/pdb3u0y/pdb
• 関連するPDBエントリー: 3IOH 3IOI 3IOJ 3U0X
• 分子名称: Histo-blood group ABO system transferase, 1-(3-phenyl-1,2,4-thiadiazol-5-yl)piperazine, URIDINE-5'-DIPHOSPHATE, ... (7 entities in total)
• 機能のキーワード: rossmann fold, "semi closed" conformation, glycosyltransferase, transferase gtb, abo, blood group antigen, glycoprotein, metal-binding, manganese, udp-gal, h-antigen acceptor, membrane, transferase, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Golgi apparatus, Golgi stack membrane; Single-pass type II membrane protein: P16442
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 71187.28

構造登録者

Palcic, M.M.,Jorgensen, R. (登録日: 2011-09-29, 公開日: 2012-10-24, 最終更新日: 2023-09-13)

• 主引用文献: Jorgensen, R.,Grimm, L.L.,Sindhuwinata, N.,Peters, T.,Palcic, M.M.; A novel compound from a molecular fragment library screen inhibits glycosyltransferases by displacing the metal ion and interfering with substrate binding; To be Published,

実験手法

X-RAY DIFFRACTION (1.6 Å)