3U0X
Crystal structure of the B-specific-1,3-galactosyltransferase (GTB) in complex with compound 382
Summary for 3U0X
Entry DOI | 10.2210/pdb3u0x/pdb |
Related | 1LZ7 1LZJ 2RIT 2RIX 2RJ8 |
Descriptor | Histo-blood group ABO system transferase, 1-(3-phenyl-1,2,4-thiadiazol-5-yl)piperazine, CHLORIDE ION, ... (6 entities in total) |
Functional Keywords | rossmann fold, open conformation, glycosyltransferase, transferase gtb, abo, blood group antigen, glycoprotein, metal-binding, manganese, udp-gal, h-antigen acceptor, membrane, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
Biological source | Homo sapiens (human) |
Cellular location | Golgi apparatus, Golgi stack membrane; Single-pass type II membrane protein: P16442 |
Total number of polymer chains | 2 |
Total formula weight | 71304.93 |
Authors | Palcic, M.M.,Jorgensen, R. (deposition date: 2011-09-29, release date: 2012-10-24, Last modification date: 2023-09-13) |
Primary citation | Jorgensen, R.,Grimm, L.L.,Sindhuwinata, N.,Peters, T.,Palcic, M.M. A novel compound from a molecular fragment library screen inhibits glycosyltransferases by displacing the metal ion and interfering with substrate binding To be Published, |
Experimental method | X-RAY DIFFRACTION (1.85 Å) |
Structure validation
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