3IOJ

Crystal structure of the Fucosylgalactoside alpha N-acetylgalactosaminyltransferase (GTA, cisAB mutant L266G, G268A) in complex with UDP

Summary for 3IOJ

Entry DOI	10.2210/pdb3ioj/pdb
Related	1LZ0 3IOH 3IOI
Descriptor	Histo-blood group ABO system transferase, MANGANESE (II) ION, URIDINE-5'-DIPHOSPHATE, ... (6 entities in total)
Functional Keywords	gta, abo, cisab mutant, aa(gly)b, rossmann fold, udp, semi-closed conformation, blood group antigen, glycoprotein, glycosyltransferase, golgi apparatus, manganese, membrane, metal-binding, polymorphism, secreted, signal-anchor, transferase, transmembrane
Biological source	Homo sapiens (human)
Cellular location	Golgi apparatus, Golgi stack membrane; Single-pass type II membrane protein: P16442
Total number of polymer chains	2
Total formula weight	70794.65
Authors	Pesnot, T.,Jorgensen, R.,Palcic, M.M.,Wagner, G.K. (deposition date: 2009-08-14, release date: 2010-04-07, Last modification date: 2023-09-06)
Primary citation	Pesnot, T.,Jorgensen, R.,Palcic, M.M.,Wagner, G.K. Structural and mechanistic basis for a new mode of glycosyltransferase inhibition. Nat.Chem.Biol., 6:321-323, 2010 Cited by PubMed: 20364127 DOI: 10.1038/nchembio.343 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.651 Å)

Structure validation