3U0Y

Crystal structure of the Fucosylgalactoside alpha N-acetylgalactosaminyltransferase (GTA, cisAB mutant L266G, G268A) in complex with compound 382 and UDP

Summary for 3U0Y

• Entry DOI: 10.2210/pdb3u0y/pdb
• Related: 3IOH 3IOI 3IOJ 3U0X
• Descriptor: Histo-blood group ABO system transferase, 1-(3-phenyl-1,2,4-thiadiazol-5-yl)piperazine, URIDINE-5'-DIPHOSPHATE, ... (7 entities in total)
• Functional Keywords: rossmann fold, "semi closed" conformation, glycosyltransferase, transferase gtb, abo, blood group antigen, glycoprotein, metal-binding, manganese, udp-gal, h-antigen acceptor, membrane, transferase, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• Biological source: Homo sapiens (human)
• Cellular location: Golgi apparatus, Golgi stack membrane; Single-pass type II membrane protein: P16442
• Total number of polymer chains: 2
• Total formula weight: 71187.28

Authors

Palcic, M.M.,Jorgensen, R. (deposition date: 2011-09-29, release date: 2012-10-24, Last modification date: 2023-09-13)

• Primary citation: Jorgensen, R.,Grimm, L.L.,Sindhuwinata, N.,Peters, T.,Palcic, M.M.; A novel compound from a molecular fragment library screen inhibits glycosyltransferases by displacing the metal ion and interfering with substrate binding; To be Published,

Experimental method

X-RAY DIFFRACTION (1.6 Å)