3U0Y
Crystal structure of the Fucosylgalactoside alpha N-acetylgalactosaminyltransferase (GTA, cisAB mutant L266G, G268A) in complex with compound 382 and UDP
Summary for 3U0Y
Entry DOI | 10.2210/pdb3u0y/pdb |
Related | 3IOH 3IOI 3IOJ 3U0X |
Descriptor | Histo-blood group ABO system transferase, 1-(3-phenyl-1,2,4-thiadiazol-5-yl)piperazine, URIDINE-5'-DIPHOSPHATE, ... (7 entities in total) |
Functional Keywords | rossmann fold, "semi closed" conformation, glycosyltransferase, transferase gtb, abo, blood group antigen, glycoprotein, metal-binding, manganese, udp-gal, h-antigen acceptor, membrane, transferase, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
Biological source | Homo sapiens (human) |
Cellular location | Golgi apparatus, Golgi stack membrane; Single-pass type II membrane protein: P16442 |
Total number of polymer chains | 2 |
Total formula weight | 71187.28 |
Authors | Palcic, M.M.,Jorgensen, R. (deposition date: 2011-09-29, release date: 2012-10-24, Last modification date: 2023-09-13) |
Primary citation | Jorgensen, R.,Grimm, L.L.,Sindhuwinata, N.,Peters, T.,Palcic, M.M. A novel compound from a molecular fragment library screen inhibits glycosyltransferases by displacing the metal ion and interfering with substrate binding To be Published, |
Experimental method | X-RAY DIFFRACTION (1.6 Å) |
Structure validation
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