3TZI

X-ray crystal structure of arachidonic acid bound in the cyclooxygenase channel of G533V murine COX-2

3TZI の概要

• エントリーDOI: 10.2210/pdb3tzi/pdb
• 関連するPDBエントリー: 1CVU 1DIY 3HS5 3KRK 3MDL 3QH0
• 分子名称: Prostaglandin G/H synthase 2, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, alpha-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (10 entities in total)
• 機能のキーワード: oxidoreductase, n-glycosylation, monotopic membrane protein
• 由来する生物種: Mus musculus (mouse)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 141404.57

構造登録者

Vecchio, A.J.,Malkowski, M.G. (登録日: 2011-09-27, 公開日: 2012-04-25, 最終更新日: 2023-09-13)

• 主引用文献: Vecchio, A.J.,Orlando, B.J.,Nandagiri, R.,Malkowski, M.G.; Investigating Substrate Promiscuity in Cyclooxygenase-2: THE ROLE OF ARG-120 AND RESIDUES LINING THE HYDROPHOBIC GROOVE.; J.Biol.Chem., 287:24619-24630, 2012; PubMed: 22637474; DOI: 10.1074/jbc.M112.372243

実験手法

X-RAY DIFFRACTION (2.15 Å)