3TZ7

Kinase domain of cSrc in complex with RL103

Summary for 3TZ7

Related3F3V 3F3W 3TZ8 3TZ9
DescriptorProto-oncogene tyrosine-protein kinase Src, N-(4-{[4-({[1-(3-aminophenyl)-3-tert-butyl-1H-pyrazol-5-yl]carbamoyl}amino)phenyl]amino}quinazolin-6-yl)-4-(dimethylamino)butanamide (2 entities in total)
Functional Keywordstype ii, allosteric, dfg-out, drug resistance mutations, tyrosin-protein kinase, transferase-transferase inhibitor complex, transferase/transferase inhibitor
Biological sourceGallus gallus (Chicken)
Cellular locationCell membrane (By similarity) P00523
Total number of polymer chains2
Total molecular weight66726.92
Authors
Gruetter, C.,Richters, A.,Rauh, D. (deposition date: 2011-09-27, release date: 2012-10-10)
Primary citation
Richters, A.,Getlik, M.,Gruetter, C.,Schneider, R.,Heuckmann, J.M.,Heynck, S.,Sos, M.L.,Thomas, R.K.,Rauh, D.
Overcoming Gatekeeper Mutations in cSrc and Abl by Hybrid Compound Design
To be Published,
Experimental method
X-RAY DIFFRACTION (3.3 Å)
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.24670.2%6.4%0.2%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution

More Asymmetric unit images

Molmil generated image of 3tz7
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Molmil generated image of 3tz7
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Molmil generated image of 3tz7
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More Biological unit images

Molmil generated image of 3tz7
no rotation
Molmil generated image of 3tz7
rotated about x axis by 90°
Molmil generated image of 3tz7
rotated about y axis by 90°
(*)In the case of coarse surface representation, the asymmetric unit is shown as red ribbon representation.
Coordinate files for Biological unit (3tz7.pdb2.gz [44.68 KB])
Coordinate files for Biological unit (3tz7.pdb1.gz [44.83 KB])