3TZ7
Kinase domain of cSrc in complex with RL103
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Proto-oncogene tyrosine-protein kinase Src | polymer | 286 | 32742.7 | 2 | UniProt (P00523) Pfam (PF07714) | Gallus gallus (Chicken) | Proto-oncogene c-Src, pp60c-src, p60-Src |
| 2 | C, D (A, B) | N-(4-{[4-({[1-(3-aminophenyl)-3-tert-butyl-1H-pyrazol-5-yl]carbamoyl}amino)phenyl]amino}quinazolin-6-yl)-4-(dimethylamino)butanamide | non-polymer | 620.7 | 2 | Chemie (AQB) |
Sequence modifications
A, B: 251 - 533 (UniProt: P00523)
| PDB | External Database | Details |
|---|---|---|
| Gly 248 | - | expression tag |
| His 249 | - | expression tag |
| Met 250 | - | expression tag |
| Cys 345 | Ser 345 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 65485.4 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 1241.5 | |
| All* | Total formula weight | 66726.9 |
