3TWU

Crystal structure of ARC4 from human Tankyrase 2 in complex with peptide from human MCL1

Summary for 3TWU

Entry DOI	10.2210/pdb3twu/pdb
Related	3TWQ 3TWR 3TWS 3TWT 3TWV 3TWW 3TWX
Descriptor	Tankyrase-2, Induced myeloid leukemia cell differentiation protein Mcl-1 (3 entities in total)
Functional Keywords	ankyrin repeat, protein-protein interaction, substrate recruitment, poly(adp-ribosyl)ation, signaling protein-peptide complex, signaling protein/peptide
Biological source	Homo sapiens (human) More
Cellular location	Cytoplasm: Q9H2K2 Membrane; Single-pass membrane protein (Potential): Q07820
Total number of polymer chains	2
Total formula weight	19714.29
Authors	Guettler, S.,Sicheri, F. (deposition date: 2011-09-22, release date: 2011-12-07, Last modification date: 2011-12-28)
Primary citation	Guettler, S.,Larose, J.,Petsalaki, E.,Gish, G.,Scotter, A.,Pawson, T.,Rottapel, R.,Sicheri, F. Structural basis and sequence rules for substrate recognition by tankyrase explain the basis for cherubism disease. Cell(Cambridge,Mass.), 147:1340-1354, 2011 Cited by PubMed: 22153077 DOI: 10.1016/j.cell.2011.10.046 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.8 Å)

Structure validation