3TWU
Crystal structure of ARC4 from human Tankyrase 2 in complex with peptide from human MCL1
Summary for 3TWU
Entry DOI | 10.2210/pdb3twu/pdb |
Related | 3TWQ 3TWR 3TWS 3TWT 3TWV 3TWW 3TWX |
Descriptor | Tankyrase-2, Induced myeloid leukemia cell differentiation protein Mcl-1 (3 entities in total) |
Functional Keywords | ankyrin repeat, protein-protein interaction, substrate recruitment, poly(adp-ribosyl)ation, signaling protein-peptide complex, signaling protein/peptide |
Biological source | Homo sapiens (human) More |
Cellular location | Cytoplasm: Q9H2K2 Membrane; Single-pass membrane protein (Potential): Q07820 |
Total number of polymer chains | 2 |
Total formula weight | 19714.29 |
Authors | Guettler, S.,Sicheri, F. (deposition date: 2011-09-22, release date: 2011-12-07, Last modification date: 2011-12-28) |
Primary citation | Guettler, S.,Larose, J.,Petsalaki, E.,Gish, G.,Scotter, A.,Pawson, T.,Rottapel, R.,Sicheri, F. Structural basis and sequence rules for substrate recognition by tankyrase explain the basis for cherubism disease. Cell(Cambridge,Mass.), 147:1340-1354, 2011 Cited by PubMed: 22153077DOI: 10.1016/j.cell.2011.10.046 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.8 Å) |
Structure validation
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