3TMZ

Crystal Structure of P450 2B4(H226Y) in complex with Amlodipine

Summary for 3TMZ

Entry DOI	10.2210/pdb3tmz/pdb
Related	1PO5 1SUO 2BDM 2Q6N 3G5N 3G93 3KW4 3ME6 3MVR 3R1A 3R1B
Descriptor	Cytochrome P450 2B4, PROTOPORPHYRIN IX CONTAINING FE, 5-CYCLOHEXYL-1-PENTYL-BETA-D-MALTOSIDE, ... (5 entities in total)
Functional Keywords	p450, cytochrome p450 2b4, monooxygenase, oxidoreductase, membrane protein, cyp 2b4
Biological source	Oryctolagus cuniculus (European rabbit,Japanese white rabbit,domestic rabbit,rabbits)
Cellular location	Endoplasmic reticulum membrane; Peripheral membrane protein: P00178
Total number of polymer chains	1
Total formula weight	56097.89
Authors	Shah, M.B.,Pascual, J.,Stout, C.D.,Halpert, J.R. (deposition date: 2011-09-01, release date: 2012-09-12, Last modification date: 2023-09-13)
Primary citation	Shah, M.B.,Wilderman, P.R.,Pascual, J.,Zhang, Q.,Stout, C.D.,Halpert, J.R. Conformational Adaptation of Human Cytochrome P450 2B6 and Rabbit Cytochrome P450 2B4 Revealed upon Binding Multiple Amlodipine Molecules. Biochemistry, 51:7225-7238, 2012 Cited by PubMed: 22909231 DOI: 10.1021/bi300894z PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.248 Å)

Structure validation