3TMZ
Crystal Structure of P450 2B4(H226Y) in complex with Amlodipine
Summary for 3TMZ
Entry DOI | 10.2210/pdb3tmz/pdb |
Related | 1PO5 1SUO 2BDM 2Q6N 3G5N 3G93 3KW4 3ME6 3MVR 3R1A 3R1B |
Descriptor | Cytochrome P450 2B4, PROTOPORPHYRIN IX CONTAINING FE, 5-CYCLOHEXYL-1-PENTYL-BETA-D-MALTOSIDE, ... (5 entities in total) |
Functional Keywords | p450, cytochrome p450 2b4, monooxygenase, oxidoreductase, membrane protein, cyp 2b4 |
Biological source | Oryctolagus cuniculus (European rabbit,Japanese white rabbit,domestic rabbit,rabbits) |
Cellular location | Endoplasmic reticulum membrane; Peripheral membrane protein: P00178 |
Total number of polymer chains | 1 |
Total formula weight | 56097.89 |
Authors | Shah, M.B.,Pascual, J.,Stout, C.D.,Halpert, J.R. (deposition date: 2011-09-01, release date: 2012-09-12, Last modification date: 2023-09-13) |
Primary citation | Shah, M.B.,Wilderman, P.R.,Pascual, J.,Zhang, Q.,Stout, C.D.,Halpert, J.R. Conformational Adaptation of Human Cytochrome P450 2B6 and Rabbit Cytochrome P450 2B4 Revealed upon Binding Multiple Amlodipine Molecules. Biochemistry, 51:7225-7238, 2012 Cited by PubMed: 22909231DOI: 10.1021/bi300894z PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.248 Å) |
Structure validation
Download full validation report