3THT

Crystal structure and RNA binding properties of the RRM/AlkB domains in human ABH8, an enzyme catalyzing tRNA hypermodification, Northeast Structural Genomics Consortium Target HR5601B

3THT の概要

• エントリーDOI: 10.2210/pdb3tht/pdb
• 関連するPDBエントリー: 3THP
• 分子名称: Alkylated DNA repair protein alkB homolog 8, ZINC ION, MANGANESE (II) ION, ... (5 entities in total)
• 機能のキーワード: structural genomics, psi-biology, northeast structural genomics consortium, nesg, alpha-beta two domain protein containing a zinc structure motif, trna modifying enzyme, oxidoreductase
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Cytoplasm : Q96BT7
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 158504.52

構造登録者

Pastore, C.,Topalidou, I.,Forouhar, F.,Yan, A.C.,Levy, M.,Hunt, J.F.,Northeast Structural Genomics Consortium (NESG) (登録日: 2011-08-19, 公開日: 2011-11-02, 最終更新日: 2023-09-13)

• 主引用文献: Pastore, C.,Topalidou, I.,Forouhar, F.,Yan, A.C.,Levy, M.,Hunt, J.F.; Crystal structure and RNA binding properties of the RNA recognition motif (RRM) and AlkB domains in human AlkB homolog 8 (ABH8), an enzyme catalyzing tRNA hypermodification.; J.Biol.Chem., 287:2130-2143, 2012; PubMed: 22065580; DOI: 10.1074/jbc.M111.286187

実験手法

X-RAY DIFFRACTION (3.01 Å)