3THT

Crystal structure and RNA binding properties of the RRM/AlkB domains in human ABH8, an enzyme catalyzing tRNA hypermodification, Northeast Structural Genomics Consortium Target HR5601B

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003676	molecular_function	nucleic acid binding
A	0003723	molecular_function	RNA binding
A	0070988	biological_process	demethylation
B	0003676	molecular_function	nucleic acid binding
B	0003723	molecular_function	RNA binding
B	0070988	biological_process	demethylation
C	0003676	molecular_function	nucleic acid binding
C	0003723	molecular_function	RNA binding
C	0070988	biological_process	demethylation
D	0003676	molecular_function	nucleic acid binding
D	0003723	molecular_function	RNA binding
D	0070988	biological_process	demethylation

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN A 401

Chain	Residue
A	HIS242
A	CYS341
A	CYS343
A	CYS349

---

site_id	AC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE MN A 402

Chain	Residue
A	HIS238
A	ASP240
A	HIS292
A	AKG403

---

site_id	AC3
Number of Residues	13
Details	BINDING SITE FOR RESIDUE AKG A 403

Chain	Residue
A	TYR229
A	ILE235
A	HIS238
A	ASP240
A	SER251
A	MET260
A	HIS292
A	ARG328
A	SER330
A	THR332
A	ARG334
A	MN402
A	ASN227

---

site_id	AC4
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN B 401

Chain	Residue
B	HIS242
B	CYS341
B	CYS343
B	CYS349

---

site_id	AC5
Number of Residues	4
Details	BINDING SITE FOR RESIDUE MN B 402

Chain	Residue
B	HIS238
B	ASP240
B	HIS292
B	AKG403

---

site_id	AC6
Number of Residues	9
Details	BINDING SITE FOR RESIDUE AKG B 403

Chain	Residue
B	ASN227
B	TYR229
B	HIS238
B	SER251
B	HIS292
B	ARG328
B	SER330
B	ARG334
B	MN402

---

site_id	AC7
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN C 401

Chain	Residue
C	HIS242
C	CYS341
C	CYS343
C	CYS349

---

site_id	AC8
Number of Residues	4
Details	BINDING SITE FOR RESIDUE MN C 402

Chain	Residue
C	HIS238
C	ASP240
C	HIS292
C	AKG403

---

site_id	AC9
Number of Residues	14
Details	BINDING SITE FOR RESIDUE AKG C 403

Chain	Residue
C	ASN227
C	TYR229
C	ILE235
C	HIS238
C	ASP240
C	SER251
C	MET260
C	HIS292
C	ILE294
C	ARG328
C	SER330
C	THR332
C	ARG334
C	MN402

---

site_id	BC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN D 401

Chain	Residue
D	HIS242
D	CYS341
D	CYS343
D	CYS349

---

site_id	BC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE MN D 402

Chain	Residue
D	HIS238
D	ASP240
D	HIS292
D	AKG403

---

site_id	BC3
Number of Residues	13
Details	BINDING SITE FOR RESIDUE AKG D 403

Chain	Residue
D	ASN227
D	TYR229
D	ILE235
D	HIS238
D	ASP240
D	SER251
D	MET260
D	HIS292
D	ARG328
D	SER330
D	THR332
D	ARG334
D	MN402

---

Functional Information from PROSITE/UniProt

site_id	PS00050
Number of Residues	16
Details	RIBOSOMAL_L23 Ribosomal protein L23 signature. KRAYVTLNgkevvddL

Chain	Residue	Details
A	LYS94-LEU109

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	308
Details	Domain: {"description":"RRM"}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	234
Details	Domain: {"description":"Fe2OG dioxygenase","evidences":[{"source":"PROSITE-ProRule","id":"PRU00805","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	32
Details	Binding site: {"evidences":[{"source":"PubMed","id":"22065580","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	12
Details	Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00805","evidenceCode":"ECO:0000255"},{"evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---