3T55

Crystal structure of Mycobacterium tuberculosis Indole Glycerol Phosphate Synthase (IGPS) in complex with Phenoxymethyl Benzoic Acid (PMBA)

Summary for 3T55

• Entry DOI: 10.2210/pdb3t55/pdb
• Related: 3QJA 3T40 3T44 3T78
• Descriptor: Indole-3-glycerol phosphate synthase, 3-(phenoxymethyl)benzoic acid, MALONATE ION, ... (5 entities in total)
• Functional Keywords: indole-3-glycerol phosphate synthase (igps), tryptophan biosynthesis, structural genomics, tb structural genomics consortium, tbsgc, transferase
• Biological source: Mycobacterium tuberculosis
• Total number of polymer chains: 1
• Total formula weight: 28479.44

Authors

Reddy, M.C.M.,Bruning, J.B.,Thurman, C.,Sacchettini, J.C.,TB Structural Genomics Consortium (TBSGC) (deposition date: 2011-07-26, release date: 2012-08-08, Last modification date: 2023-09-13)

• Primary citation: Reddy, M.C.M.,Bruning, J.B.,Thurman, C.,Sacchettini, J.C.; Structural Insights and Inhibition of Mycobacterium tuberculosis Indole Glycerol Phosphate Synthase (IGPS): an Essential Enzyme for Tryptophan Biosynthesis; To be Published,

Experimental method

X-RAY DIFFRACTION (2.06 Å)