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3T55

Crystal structure of Mycobacterium tuberculosis Indole Glycerol Phosphate Synthase (IGPS) in complex with Phenoxymethyl Benzoic Acid (PMBA)

Functional Information from GO Data
ChainGOidnamespacecontents
A0000162biological_processtryptophan biosynthetic process
A0000287molecular_functionmagnesium ion binding
A0004425molecular_functionindole-3-glycerol-phosphate synthase activity
A0004640molecular_functionphosphoribosylanthranilate isomerase activity
A0005886cellular_componentplasma membrane
A0006568biological_processtryptophan metabolic process
A0009274cellular_componentpeptidoglycan-based cell wall
A0016830molecular_functioncarbon-carbon lyase activity
A0016831molecular_functioncarboxy-lyase activity
A0046391biological_process5-phosphoribose 1-diphosphate metabolic process
Functional Information from PDB Data
site_idAC1
Number of Residues13
DetailsBINDING SITE FOR RESIDUE 4RG A 273
ChainResidue
ASER62
ALEU193
ALEU196
AHOH316
AHOH382
APRO63
ASER64
APHE98
ALYS119
AASP120
APHE121
ALEU140
AARG191

site_idAC2
Number of Residues10
DetailsBINDING SITE FOR RESIDUE MLI A 274
ChainResidue
ALYS59
AARG191
ASER220
ALEU240
AGLY242
AGLU243
AHOH289
AHOH307
AHOH314
AHOH426

site_idAC3
Number of Residues8
DetailsBINDING SITE FOR RESIDUE SO4 A 275
ChainResidue
ALEU27
ALYS31
AALA72
APRO74
AASP103
AARG157
AHOH299
AHOH303

Functional Information from PROSITE/UniProt
site_idPS00614
Number of Residues18
DetailsIGPS Indole-3-glycerol phosphate synthase signature. VIaEVKRASPSagalat.I
ChainResidueDetails
AVAL54-ILE71

221051

PDB entries from 2024-06-12

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