3T2N
Human hepsin protease in complex with the Fab fragment of an inhibitory antibody
Summary for 3T2N
Entry DOI | 10.2210/pdb3t2n/pdb |
Related | 1O5E 1P57 1Z8G |
Descriptor | Serine protease hepsin, Antibody, Fab fragment, Heavy Chain, Antibody, Fab fragment, Light Chain, ... (4 entities in total) |
Functional Keywords | type ii transmembrane serine protease, srcr domain, substrates include pro-hepsin, pro-hgf, laminin-332, transmembrane, hydrolase |
Biological source | Homo sapiens (human) More |
Cellular location | Membrane; Single-pass type II membrane protein: P05981 |
Total number of polymer chains | 6 |
Total formula weight | 174682.21 |
Authors | Koschubs, T.,Dengl, S.,Duerr, H.,Kaluza, K.,Georges, G.,Hartl, C.,Jennewein, S.,Lanzendoerfer, M.,Auer, J.,Stern, A.,Huang, K.-S.,Kostrewa, D.,Ries, S.,Hansen, S.,Kohnert, U.,Cramer, P.,Mundigl, O. (deposition date: 2011-07-22, release date: 2011-12-28, Last modification date: 2012-07-25) |
Primary citation | Koschubs, T.,Dengl, S.,Durr, H.,Kaluza, K.,Georges, G.,Hartl, C.,Jennewein, S.,Lanzendorfer, M.,Auer, J.,Stern, A.,Huang, K.S.,Packman, K.,Gubler, U.,Kostrewa, D.,Ries, S.,Hansen, S.,Kohnert, U.,Cramer, P.,Mundigl, O. Allosteric antibody inhibition of human hepsin protease. Biochem.J., 442:483-494, 2012 Cited by PubMed: 22132769DOI: 10.1042/BJ20111317 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.55 Å) |
Structure validation
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