3T2N

Human hepsin protease in complex with the Fab fragment of an inhibitory antibody

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004252	molecular_function	serine-type endopeptidase activity
A	0006508	biological_process	proteolysis
A	0016020	cellular_component	membrane
A	0070008	molecular_function	serine-type exopeptidase activity
B	0004252	molecular_function	serine-type endopeptidase activity
B	0006508	biological_process	proteolysis
B	0016020	cellular_component	membrane
B	0070008	molecular_function	serine-type exopeptidase activity

Functional Information from PROSITE/UniProt

site_id	PS00134
Number of Residues	6
Details	TRYPSIN_HIS Serine proteases, trypsin family, histidine active site. LTAAHC

Chain	Residue	Details
A	LEU199-CYS204

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site_id	PS00135
Number of Residues	12
Details	TRYPSIN_SER Serine proteases, trypsin family, serine active site. DAcqGDSGGPFV

Chain	Residue	Details
A	ASP347-VAL358

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site_id	PS00290
Number of Residues	7
Details	IG_MHC Immunoglobulins and major histocompatibility complex proteins signature. YSCQVTH

Chain	Residue	Details
L	TYR192-HIS198
H	TYR194-HIS200

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	6
Details	ACT_SITE: Charge relay system => ECO:0000305|PubMed:12962630, ECO:0000305|PubMed:15839837

Chain	Residue	Details
A	HIS203
A	ASP257
A	SER353
B	HIS203
B	ASP257
B	SER353

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site_id	SWS_FT_FI2
Number of Residues	2
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:19159218

Chain	Residue	Details
A	ASN112
B	ASN112

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