1Z8G

Crystal structure of the extracellular region of the transmembrane serine protease hepsin with covalently bound preferred substrate.

Summary for 1Z8G

Related PRD IDPRD_000307
DescriptorSerine protease hepsin, ACE-LYS-GLN-LEU-ARG-Chloromethylketone (3 entities in total)
Functional Keywordsserine protease hepsin, protease, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
Biological sourceHomo sapiens (human)
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Cellular locationMembrane; Single-pass type II membrane protein P05981
Total number of polymer chains2
Total molecular weight41054.97
Authors
Herter, S.,Piper, D.E.,Aaron, W.,Gabriele, T.,Cutler, G.,Cao, P.,Bhatt, A.S.,Choe, Y.,Craik, C.S.,Walker, N.,Meininger, D.,Hoey, T.,Austin, R.J. (deposition date: 2005-03-30, release date: 2005-05-03, Last modification date: 2012-12-12)
Primary citation
Herter, S.,Piper, D.E.,Aaron, W.,Gabriele, T.,Cutler, G.,Cao, P.,Bhatt, A.S.,Choe, Y.,Craik, C.S.,Walker, N.,Meininger, D.,Hoey, T.,Austin, R.J.
Hepatocyte growth factor is a preferred in vitro substrate for human hepsin, a membrane-anchored serine protease implicated in prostate and ovarian cancers
Biochem.J., 390:125-136, 2005
PubMed: 15839837 (PDB entries with the same primary citation)
DOI: 10.1042/BJ20041955
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (1.55 Å)
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.206200.3%7.0%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
Download full validation report