1Z8G

Crystal structure of the extracellular region of the transmembrane serine protease hepsin with covalently bound preferred substrate.

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004252	molecular_function	serine-type endopeptidase activity
A	0006508	biological_process	proteolysis
A	0016020	cellular_component	membrane
A	0070008	molecular_function	serine-type exopeptidase activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	26
Details	BINDING SITE FOR CHAIN L OF ACE-LYS-GLN-LEU-ARG-CHLOROMETHYLKETONE

Chain	Residue
A	HIS203
A	GLN350
A	GLY351
A	SER353
A	SER376
A	TRP377
A	GLY378
A	THR379
A	GLY380
A	CYS381
A	GLY388
A	TYR243
A	HOH476
A	HOH524
L	HOH188
L	HOH267
L	HOH268
L	HOH302
L	HOH409
A	GLU252
A	ASN254
A	TYR301
A	GLN331
A	ASP347
A	ALA348
A	CYS349

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Functional Information from PROSITE/UniProt

site_id	PS00134
Number of Residues	6
Details	TRYPSIN_HIS Serine proteases, trypsin family, histidine active site. LTAAHC

Chain	Residue	Details
A	LEU199-CYS204

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site_id	PS00135
Number of Residues	12
Details	TRYPSIN_SER Serine proteases, trypsin family, serine active site. DAcqGDSGGPFV

Chain	Residue	Details
A	ASP347-VAL358

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	3
Details	ACT_SITE: Charge relay system => ECO:0000305|PubMed:12962630, ECO:0000305|PubMed:15839837

Chain	Residue	Details
A	HIS203
A	ASP257
A	SER353

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site_id	SWS_FT_FI2
Number of Residues	1
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:19159218

Chain	Residue	Details
A	ALA112

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