3SMJ
Human poly(ADP-ribose) polymerase 14 (Parp14/Artd8) - catalytic domain in complex with a pyrimidine-like inhibitor
Summary for 3SMJ
Entry DOI | 10.2210/pdb3smj/pdb |
Related | 3GOY 3SE2 3SMI |
Descriptor | Poly [ADP-ribose] polymerase 14, 2-methyl-3,5,6,7-tetrahydro-4H-cyclopenta[4,5]thieno[2,3-d]pyrimidin-4-one, GLYCEROL, ... (4 entities in total) |
Functional Keywords | diphtheria toxin like fold, transferase, nad+, adp-ribosylation, transferase-transferase inhibitor complex, structural genomics, structural genomics consortium, sgc, transferase/transferase inhibitor |
Biological source | Homo sapiens (human) |
Cellular location | Nucleus: Q460N5 |
Total number of polymer chains | 2 |
Total formula weight | 44741.80 |
Authors | Karlberg, T.,Moche, M.,Arrowsmith, C.H.,Berglund, H.,Bountra, C.,Edwards, A.M.,Ekblad, T.,Graslund, S.,Kouznetsova, E.,Nordlund, P.,Nyman, T.,Thorsell, A.G.,Tresaugues, L.,Weigelt, J.,Schuler, H.,Structural Genomics Consortium (SGC) (deposition date: 2011-06-28, release date: 2011-07-20, Last modification date: 2023-09-13) |
Primary citation | Wahlberg, E.,Karlberg, T.,Kouznetsova, E.,Markova, N.,Macchiarulo, A.,Thorsell, A.G.,Pol, E.,Frostell, A.,Ekblad, T.,Oncu, D.,Kull, B.,Robertson, G.M.,Pellicciari, R.,Schuler, H.,Weigelt, J. Family-wide chemical profiling and structural analysis of PARP and tankyrase inhibitors. Nat.Biotechnol., 30:283-288, 2012 Cited by PubMed: 22343925DOI: 10.1038/nbt.2121 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.5 Å) |
Structure validation
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