3SE2
Human poly(ADP-ribose) polymerase 14 (PARP14/ARTD8) - catalytic domain in complex with 6(5H)-phenanthridinone
Summary for 3SE2
Entry DOI | 10.2210/pdb3se2/pdb |
Related | 3GOY 3SMI |
Descriptor | Poly [ADP-ribose] polymerase 14, phenanthridin-6(5H)-one, GLYCEROL, ... (7 entities in total) |
Functional Keywords | diphtheria toxin like fold, transferase, nad+, adp-ribosylation, structural genomics, structural genomics consortium, sgc |
Biological source | Homo sapiens (human) |
Cellular location | Nucleus : Q460N5 |
Total number of polymer chains | 4 |
Total formula weight | 89750.62 |
Authors | Karlberg, T.,Schutz, P.,Arrowsmith, C.H.,Berglund, H.,Bountra, C.,Collins, R.,Edwards, A.M.,Ekblad, T.,Graslund, S.,Kouznetsova, E.,Moche, M.,Nordlund, P.,Nyman, T.,Thorsell, A.G.,Tresaugues, L.,Weigelt, J.,Siponen, M.I.,Schuler, H.,Structural Genomics Consortium (SGC) (deposition date: 2011-06-10, release date: 2011-07-06, Last modification date: 2023-09-13) |
Primary citation | Wahlberg, E.,Karlberg, T.,Kouznetsova, E.,Markova, N.,Macchiarulo, A.,Thorsell, A.G.,Pol, E.,Frostell, A.,Ekblad, T.,Oncu, D.,Kull, B.,Robertson, G.M.,Pellicciari, R.,Schuler, H.,Weigelt, J. Family-wide chemical profiling and structural analysis of PARP and tankyrase inhibitors. Nat.Biotechnol., 30:283-288, 2012 Cited by PubMed: 22343925DOI: 10.1038/nbt.2121 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.3 Å) |
Structure validation
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