3SE2

Human poly(ADP-ribose) polymerase 14 (PARP14/ARTD8) - catalytic domain in complex with 6(5H)-phenanthridinone

Summary for 3SE2

Entry DOI	10.2210/pdb3se2/pdb
Related	3GOY 3SMI
Descriptor	Poly [ADP-ribose] polymerase 14, phenanthridin-6(5H)-one, GLYCEROL, ... (7 entities in total)
Functional Keywords	diphtheria toxin like fold, transferase, nad+, adp-ribosylation, structural genomics, structural genomics consortium, sgc
Biological source	Homo sapiens (human)
Cellular location	Nucleus : Q460N5
Total number of polymer chains	4
Total formula weight	89750.62
Authors	Karlberg, T.,Schutz, P.,Arrowsmith, C.H.,Berglund, H.,Bountra, C.,Collins, R.,Edwards, A.M.,Ekblad, T.,Graslund, S.,Kouznetsova, E.,Moche, M.,Nordlund, P.,Nyman, T.,Thorsell, A.G.,Tresaugues, L.,Weigelt, J.,Siponen, M.I.,Schuler, H.,Structural Genomics Consortium (SGC) (deposition date: 2011-06-10, release date: 2011-07-06, Last modification date: 2023-09-13)
Primary citation	Wahlberg, E.,Karlberg, T.,Kouznetsova, E.,Markova, N.,Macchiarulo, A.,Thorsell, A.G.,Pol, E.,Frostell, A.,Ekblad, T.,Oncu, D.,Kull, B.,Robertson, G.M.,Pellicciari, R.,Schuler, H.,Weigelt, J. Family-wide chemical profiling and structural analysis of PARP and tankyrase inhibitors. Nat.Biotechnol., 30:283-288, 2012 Cited by PubMed: 22343925 DOI: 10.1038/nbt.2121 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.3 Å)

Structure validation