3SMI

Human poly(ADP-ribose) polymerase 14 (Parp14/Artd8) - catalytic domain in complex with a quinazoline inhibitor

Summary for 3SMI

• Entry DOI: 10.2210/pdb3smi/pdb
• Related: 3GOY 3SE2
• Descriptor: Poly [ADP-ribose] polymerase 14, 2-{[(3-amino-1H-1,2,4-triazol-5-yl)sulfanyl]methyl}-8-methylquinazolin-4(3H)-one (3 entities in total)
• Functional Keywords: diphtheria toxin like fold, transferase, nad+, adp-ribosylation, transferase-transferase inhibitor complex, structural genomics, structural genomics consortium, sgc, transferase/transferase inhibitor
• Biological source: Homo sapiens (human)
• Cellular location: Nucleus: Q460N5
• Total number of polymer chains: 2
• Total formula weight: 44813.84

Authors

Karlberg, T.,Moche, M.,Arrowsmith, C.H.,Berglund, H.,Bountra, C.,Edwards, A.M.,Ekblad, T.,Graslund, S.,Kouznetsova, E.,Nordlund, P.,Nyman, T.,Thorsell, A.G.,Tresaugues, L.,Weigelt, J.,Schuler, H.,Structural Genomics Consortium (SGC) (deposition date: 2011-06-28, release date: 2011-07-20, Last modification date: 2023-09-13)

• Primary citation: Wahlberg, E.,Karlberg, T.,Kouznetsova, E.,Markova, N.,Macchiarulo, A.,Thorsell, A.G.,Pol, E.,Frostell, A.,Ekblad, T.,Oncu, D.,Kull, B.,Robertson, G.M.,Pellicciari, R.,Schuler, H.,Weigelt, J.; Family-wide chemical profiling and structural analysis of PARP and tankyrase inhibitors.; Nat.Biotechnol., 30:283-288, 2012; PubMed: 22343925; DOI: 10.1038/nbt.2121

Experimental method

X-RAY DIFFRACTION (2.4 Å)