3SMJ
Human poly(ADP-ribose) polymerase 14 (Parp14/Artd8) - catalytic domain in complex with a pyrimidine-like inhibitor
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Poly [ADP-ribose] polymerase 14 | polymer | 193 | 22118.6 | 2 | UniProt (Q460N5) Pfam (PF00644) | Homo sapiens (human) | PARP-14, B aggressive lymphoma protein 2 |
| 2 | C, E (A, B) | 2-methyl-3,5,6,7-tetrahydro-4H-cyclopenta[4,5]thieno[2,3-d]pyrimidin-4-one | non-polymer | 206.3 | 2 | Chemie (FDR) | |||
| 3 | D (A) | GLYCEROL | non-polymer | 92.1 | 1 | Chemie (GOL) | |||
| 4 | F, G (A, B) | water | water | 18.0 | 290 | Chemie (HOH) |
Sequence modifications
A, B: 1530 - 1720 (UniProt: Q460N5)
| PDB | External Database | Details |
|---|---|---|
| Ser 1528 | - | expression tag |
| Met 1529 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 44237.2 | |
| Non-Polymers* | Number of molecules | 3 |
| Total formula weight | 504.6 | |
| All* | Total formula weight | 44741.8 |
