3SH2

Staphylococcus aureus Dihydrofolate Reductase complexed with NADPH and 6-ethyl-5-(3-(4-methoxybiphenyl-3-yl)prop-1-ynyl)pyrimidine-2,4-diamine (UCP120J)

3SH2 の概要

• エントリーDOI: 10.2210/pdb3sh2/pdb
• 関連するPDBエントリー: 3F0B 3F0Q 3F0S 3SGY
• 分子名称: Dihydrofolate reductase, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, 6-ethyl-5-[3-(4-methoxybiphenyl-3-yl)prop-1-yn-1-yl]pyrimidine-2,4-diamine (3 entities in total)
• 機能のキーワード: oxidoreductase, nadp, nadph, one-carbon metabolism, oxidoreductase-oxidoreductase inhibitor complex, oxidoreductase/oxidoreductase inhibitor
• 由来する生物種: Staphylococcus aureus
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 40933.72

構造登録者

Frey, K.M.,Anderson, A.C. (登録日: 2011-06-15, 公開日: 2012-03-07, 最終更新日: 2024-04-03)

• 主引用文献: Viswanathan, K.,Frey, K.M.,Scocchera, E.W.,Martin, B.D.,Swain Iii, P.W.,Alverson, J.B.,Priestley, N.D.,Anderson, A.C.,Wright, D.L.; Toward New Therapeutics for Skin and Soft Tissue Infections: Propargyl-Linked Antifolates Are Potent Inhibitors of MRSA and Streptococcus pyogenes.; Plos One, 7:e29434-e29434, 2012; PubMed: 22347365; DOI: 10.1371/journal.pone.0029434

実験手法

X-RAY DIFFRACTION (2.999 Å)