3SGY
Staphylococcus aureus Dihydrofolate Reductase complexed with NADPH and 6-ETHYL-5-[(3S)-3-[3-METHOXY-5-(PYRIDIN-4-YL)PHENYL]BUT-1-YN-1-YL]PYRIMIDINE-2,4-DIAMINE (UCP1006)
3SGY の概要
エントリーDOI | 10.2210/pdb3sgy/pdb |
関連するPDBエントリー | 3F0B 3F0Q 3F0S 3SH2 |
分子名称 | Dihydrofolate reductase, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, 6-ethyl-5-{(3S)-3-[3-methoxy-5-(pyridin-4-yl)phenyl]but-1-yn-1-yl}pyrimidine-2,4-diamine, ... (4 entities in total) |
機能のキーワード | oxidoreductase, nadp, nadph, one-carbon metabolism, oxidoreductase-oxidoreductase inhibitor complex, oxidoreductase/oxidoreductase inhibitor |
由来する生物種 | Staphylococcus aureus |
タンパク質・核酸の鎖数 | 2 |
化学式量合計 | 40963.75 |
構造登録者 | |
主引用文献 | Viswanathan, K.,Frey, K.M.,Scocchera, E.W.,Martin, B.D.,Swain Iii, P.W.,Alverson, J.B.,Priestley, N.D.,Anderson, A.C.,Wright, D.L. Toward New Therapeutics for Skin and Soft Tissue Infections: Propargyl-Linked Antifolates Are Potent Inhibitors of MRSA and Streptococcus pyogenes. Plos One, 7:e29434-e29434, 2012 Cited by PubMed: 22347365DOI: 10.1371/journal.pone.0029434 主引用文献が同じPDBエントリー |
実験手法 | X-RAY DIFFRACTION (2.598 Å) |
構造検証レポート
検証レポート(詳細版)をダウンロード