3RBB

HIV-1 NEF protein in complex with engineered HCK SH3 domain

Summary for 3RBB

Entry DOI	10.2210/pdb3rbb/pdb
Related	1AVZ 1EFN 2NEF 3REA 3REB
Descriptor	Protein Nef, Tyrosine-protein kinase HCK, 1,2-ETHANEDIOL, ... (4 entities in total)
Functional Keywords	hiv-1 nef, dileucine motif, sh3 domain, receptor internalization, pxxp motif, protein binding, viral protein
Biological source	HIV-1 M:B_ARV2/SF2 (HIV-1) More
Cellular location	Host cell membrane; Lipid-anchor; Cytoplasmic side (By similarity): P03407 Isoform p59-HCK: Membrane; Lipid-anchor. Isoform p60-HCK: Membrane; Lipid-anchor: P08631
Total number of polymer chains	4
Total formula weight	52699.03
Authors	Horenkamp, F.A.,Schulte, A.,Weyand, M.,Geyer, M. (deposition date: 2011-03-29, release date: 2011-04-27, Last modification date: 2023-09-13)
Primary citation	Horenkamp, F.A.,Breuer, S.,Schulte, A.,Lulf, S.,Weyand, M.,Saksela, K.,Geyer, M. Conformation of the Dileucine-Based Sorting Motif in HIV-1 Nef Revealed by Intermolecular Domain Assembly. Traffic, 12:867-877, 2011 Cited by PubMed: 21477083 DOI: 10.1111/j.1600-0854.2011.01205.x PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.35 Å)

Structure validation