3QV7

Crystal structure of Leishmania mexicana pyruvate kinase(LmPYK)in complex with ponceau S and acid blue 25.

3QV7 の概要

• エントリーDOI: 10.2210/pdb3qv7/pdb
• 関連するPDBエントリー: 1PKL 3QV6 3QV8 3QV9
• 分子名称: Pyruvate kinase, SULFATE ION, POTASSIUM ION, ... (6 entities in total)
• 機能のキーワード: pyruvate kinase, glycolysis, tim barrel, sugar kinase, adp/atp binding, cytosol, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• 由来する生物種: Leishmania mexicana
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 222311.36

構造登録者

Morgan, H.P.,Auld, D.S.,McNae, I.W.,Nowicki, M.W.,Michels, P.A.M.,Fothergill-Gilmore, L.A.,Walkinshaw, M.D. (登録日: 2011-02-25, 公開日: 2011-06-29, 最終更新日: 2023-09-13)

• 主引用文献: Morgan, H.P.,McNae, I.W.,Nowicki, M.W.,Zhong, W.,Michels, P.A.,Auld, D.S.,Fothergill-Gilmore, L.A.,Walkinshaw, M.D.; The trypanocidal drug suramin and other trypan blue mimetics are inhibitors of pyruvate kinases and bind to the adenosine site.; J.Biol.Chem., 286:31232-31240, 2011; PubMed: 21733839; DOI: 10.1074/jbc.M110.212613

実験手法

X-RAY DIFFRACTION (2.7 Å)