3QPO

Structure of PDE10-inhibitor complex

Summary for 3QPO

Entry DOI	10.2210/pdb3qpo/pdb
Related	2O8H 2OVV 2OVY 3QPN 3QPP
Descriptor	cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A, SULFATE ION, ZINC ION, ... (6 entities in total)
Functional Keywords	phosphodiesterase inhibitors, structure-based drug design, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
Biological source	Rattus norvegicus (brown rat,rat,rats)
Cellular location	Cytoplasm: Q9QYJ6
Total number of polymer chains	1
Total formula weight	42384.09
Authors	Pandit, J.,Marr, E.S. (deposition date: 2011-02-14, release date: 2011-06-15, Last modification date: 2024-02-21)
Primary citation	Helal, C.J.,Kang, Z.,Hou, X.,Pandit, J.,Chappie, T.A.,Humphrey, J.M.,Marr, E.S.,Fennell, K.F.,Chenard, L.K.,Fox, C.,Schmidt, C.J.,Williams, R.D.,Chapin, D.S.,Siuciak, J.,Lebel, L.,Menniti, F.,Cianfrogna, J.,Fonseca, K.R.,Nelson, F.R.,O'Connor, R.,Macdougall, M.,McDowell, L.,Liras, S. Use of Structure-Based Design to Discover a Potent, Selective, In Vivo Active Phosphodiesterase 10A Inhibitor Lead Series for the Treatment of Schizophrenia. J.Med.Chem., 54:4536-4547, 2011 Cited by PubMed: 21650160 DOI: 10.1021/jm2001508 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.8 Å)

Structure validation