3QPN
Structure of PDE10-inhibitor complex
Summary for 3QPN
Entry DOI | 10.2210/pdb3qpn/pdb |
Related | 2O8H 2OVV 2OVY 3QPO 3QPP |
Descriptor | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A, SULFATE ION, ZINC ION, ... (6 entities in total) |
Functional Keywords | phosphodiesterase inhibitors, structure-based drug design, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor |
Biological source | Rattus norvegicus (brown rat,rat,rats) |
Cellular location | Cytoplasm: Q9QYJ6 |
Total number of polymer chains | 1 |
Total formula weight | 42178.86 |
Authors | Pandit, J.,Marr, E.S. (deposition date: 2011-02-14, release date: 2011-06-15, Last modification date: 2024-02-21) |
Primary citation | Helal, C.J.,Kang, Z.,Hou, X.,Pandit, J.,Chappie, T.A.,Humphrey, J.M.,Marr, E.S.,Fennell, K.F.,Chenard, L.K.,Fox, C.,Schmidt, C.J.,Williams, R.D.,Chapin, D.S.,Siuciak, J.,Lebel, L.,Menniti, F.,Cianfrogna, J.,Fonseca, K.R.,Nelson, F.R.,O'Connor, R.,Macdougall, M.,McDowell, L.,Liras, S. Use of Structure-Based Design to Discover a Potent, Selective, In Vivo Active Phosphodiesterase 10A Inhibitor Lead Series for the Treatment of Schizophrenia. J.Med.Chem., 54:4536-4547, 2011 Cited by PubMed: 21650160DOI: 10.1021/jm2001508 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2 Å) |
Structure validation
Download full validation report