3QPO
Structure of PDE10-inhibitor complex
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | polymer | 362 | 41661.7 | 1 | UniProt (Q9QYJ6) Pfam (PF00233) | Rattus norvegicus (brown rat rat rats) | |
| 2 | B, C (A) | SULFATE ION | non-polymer | 96.1 | 2 | Chemie (SO4) | |||
| 3 | D (A) | ZINC ION | non-polymer | 65.4 | 1 | Chemie (ZN) | |||
| 4 | E (A) | MAGNESIUM ION | non-polymer | 24.3 | 1 | Chemie (MG) | |||
| 5 | F (A) | 7-methoxy-4-[(3S)-3-phenylpiperidin-1-yl]-6-[2-(pyridin-2-yl)ethoxy]quinazoline | non-polymer | 440.5 | 1 | Chemie (PFR) | |||
| 6 | G (A) | water | water | 18.0 | 176 | Chemie (HOH) |
Sequence modifications
A: 442 - 784 (UniProt: Q9QYJ6)
| PDB | External Database | Details |
|---|---|---|
| Met 423 | - | expression tag |
| His 424 | - | expression tag |
| His 425 | - | expression tag |
| His 426 | - | expression tag |
| His 427 | - | expression tag |
| His 428 | - | expression tag |
| His 429 | - | expression tag |
| Ser 430 | - | expression tag |
| Ser 431 | - | expression tag |
| Gly 432 | - | expression tag |
| Leu 433 | - | expression tag |
| Val 434 | - | expression tag |
| Pro 435 | - | expression tag |
| Arg 436 | - | expression tag |
| Gly 437 | - | expression tag |
| Ser 438 | - | expression tag |
| Ala 439 | - | expression tag |
| Met 440 | - | expression tag |
| Gly 441 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 41661.7 | |
| Non-Polymers* | Number of molecules | 5 |
| Total formula weight | 722.4 | |
| All* | Total formula weight | 42384.1 |
