3QE0
A Galpha-i1 P-loop mutation prevents transition to the activated state
Summary for 3QE0
Entry DOI | 10.2210/pdb3qe0/pdb |
Related | 1kjy 1Y3A 2OM2 3QI2 |
Descriptor | Guanine nucleotide-binding protein G(i) subunit alpha-1, KB752 peptide, MAGNESIUM ION, ... (5 entities in total) |
Functional Keywords | kb752, ras-like domain, all-helical domain, arginine finger, signaling protein, lipoprotein, transducer, gtpase activity, gtp binding, nucleotide binding, adp-ribosylation |
Biological source | Homo sapiens (human) More |
Cellular location | Nucleus (By similarity): P63096 |
Total number of polymer chains | 5 |
Total formula weight | 117216.34 |
Authors | Bosch, D.E.,Willard, F.S.,Kimple, A.J.,Miley, M.J.,Siderovski, D.P. (deposition date: 2011-01-19, release date: 2012-01-25, Last modification date: 2023-09-13) |
Primary citation | Bosch, D.E.,Willard, F.S.,Ramanujam, R.,Kimple, A.J.,Willard, M.D.,Naqvi, N.I.,Siderovski, D.P. A P-loop Mutation in Galpha Subunits Prevents Transition to the Active State: Implications for G-protein Signaling in Fungal Pathogenesis Plos Pathog., 8:e1002553-e1002553, 2012 Cited by PubMed: 22383884DOI: 10.1371/journal.ppat.1002553 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (3 Å) |
Structure validation
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