3PXY

CDK2 in complex with inhibitor JWS648

Summary for 3PXY

Related3PXF 3PXQ 3PXR 3PXZ 3PY0 3PY1
DescriptorCell division protein kinase 2, 2-(4,6-diamino-1,3,5-triazin-2-yl)-4-methoxyphenol, PHOSPHATE ION, ... (4 entities in total)
Functional Keywordsprotein kinase, cdk2, inhibitor, transferase-transferase inhibitor complex, transferase/transferase inhibitor
Biological sourceHomo sapiens (human)
Total number of polymer chains1
Total molecular weight35089.55
Authors
Han, H.,Betzi, S.,Alam, R.,Schonbrunn, E. (deposition date: 2010-12-10, release date: 2011-02-16, Last modification date: 2011-07-13)
Primary citation
Betzi, S.,Alam, R.,Martin, M.,Lubbers, D.J.,Han, H.,Jakkaraj, S.R.,Georg, G.I.,Schonbrunn, E.
Discovery of a Potential Allosteric Ligand Binding Site in CDK2.
Acs Chem.Biol., 6:492-501, 2011
PubMed: 21291269 (PDB entries with the same primary citation)
DOI: 10.1021/cb100410m
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (1.8 Å)
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.247162.4%3.9%19.4%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
Download full validation report