3PP0
Crystal Structure of the Kinase domain of Human HER2 (erbB2).
Summary for 3PP0
Entry DOI | 10.2210/pdb3pp0/pdb |
Related | 3POZ |
Descriptor | Receptor tyrosine-protein kinase erbB-2, 2-{2-[4-({5-chloro-6-[3-(trifluoromethyl)phenoxy]pyridin-3-yl}amino)-5H-pyrrolo[3,2-d]pyrimidin-5-yl]ethoxy}ethanol (3 entities in total) |
Functional Keywords | kinase domain, anti-oncogene, atp-binding, cell cycle, disease mutation, glycoprotein, membrane, nucleotide-binding, phosphoprotein, receptor, secreted, transferase, transmembrane, tyrosine-protein kinase, tyrosine kinase inhibitor, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
Biological source | Homo sapiens (human) |
Cellular location | Isoform 1: Cell membrane; Single-pass type I membrane protein. Isoform 2: Cytoplasm. Isoform 3: Cytoplasm: P04626 |
Total number of polymer chains | 2 |
Total formula weight | 77445.76 |
Authors | Skene, R.J.,Aertgeerts, K.,Sogabe, S. (deposition date: 2010-11-23, release date: 2011-03-30, Last modification date: 2023-09-06) |
Primary citation | Aertgeerts, K.,Skene, R.,Yano, J.,Sang, B.C.,Zou, H.,Snell, G.,Jennings, A.,Iwamoto, K.,Habuka, N.,Hirokawa, A.,Ishikawa, T.,Tanaka, T.,Miki, H.,Ohta, Y.,Sogabe, S. Structural Analysis of the Mechanism of Inhibition and Allosteric Activation of the Kinase Domain of HER2 Protein. J.Biol.Chem., 286:18756-18765, 2011 Cited by PubMed: 21454582DOI: 10.1074/jbc.M110.206193 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.25 Å) |
Structure validation
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