3POZ

EGFR Kinase domain complexed with tak-285

Summary for 3POZ

• Entry DOI: 10.2210/pdb3poz/pdb
• Related: 3PP0
• Descriptor: Epidermal growth factor receptor, SULFATE ION, N-{2-[4-({3-chloro-4-[3-(trifluoromethyl)phenoxy]phenyl}amino)-5H-pyrrolo[3,2-d]pyrimidin-5-yl]ethyl}-3-hydroxy-3-methylbutanamide, ... (4 entities in total)
• Functional Keywords: kinase domain, anti-oncogene, atp-binding, cell cycle, disease mutation, glycoprotein, membrane, nucleotide-binding, phosphoprotein, receptor, secreted, transferase, transmembrane, tyrosine-protein kinase, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• Biological source: Homo sapiens (human)
• Cellular location: Cell membrane; Single-pass type I membrane protein. Isoform 2: Secreted: P00533
• Total number of polymer chains: 1
• Total formula weight: 38140.28

Authors

Aertgeerts, K.,Skene, R.,Sogabe, S. (deposition date: 2010-11-23, release date: 2011-03-30, Last modification date: 2023-09-06)

• Primary citation: Aertgeerts, K.,Skene, R.,Yano, J.,Sang, B.C.,Zou, H.,Snell, G.,Jennings, A.,Iwamoto, K.,Habuka, N.,Hirokawa, A.,Ishikawa, T.,Tanaka, T.,Miki, H.,Ohta, Y.,Sogabe, S.; Structural Analysis of the Mechanism of Inhibition and Allosteric Activation of the Kinase Domain of HER2 Protein.; J.Biol.Chem., 286:18756-18765, 2011; PubMed: 21454582; DOI: 10.1074/jbc.M110.206193

Experimental method

X-RAY DIFFRACTION (1.5 Å)