3PP0
Crystal Structure of the Kinase domain of Human HER2 (erbB2).
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Receptor tyrosine-protein kinase erbB-2 | polymer | 338 | 38229.0 | 2 | UniProt (P04626) Pfam (PF07714) | Homo sapiens (human) | Metastatic lymph node gene 19 protein, MLN 19, Proto-oncogene Neu, Proto-oncogene c-ErbB-2, Tyrosine kinase-type cell surface receptor HER2, p185erbB2 |
| 2 | C, D (A, B) | 2-{2-[4-({5-chloro-6-[3-(trifluoromethyl)phenoxy]pyridin-3-yl}amino)-5H-pyrrolo[3,2-d]pyrimidin-5-yl]ethoxy}ethanol | non-polymer | 493.9 | 2 | Chemie (03Q) | |||
| 3 | E, F (A, B) | water | water | 18.0 | 190 | Chemie (HOH) |
Sequence modifications
A, B: 706 - 1009 (UniProt: P04626)
| PDB | External Database | Details |
|---|---|---|
| Ala 706 | Met 706 | engineered mutation |
| Leu 711 | Gln 711 | engineered mutation |
| Leu 712 | Met 712 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 76458.0 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 987.7 | |
| All* | Total formula weight | 77445.8 |
