3PHD

Crystal structure of human HDAC6 in complex with ubiquitin

Summary for 3PHD

• Entry DOI: 10.2210/pdb3phd/pdb
• Related: 2ZNV 3C5K 3GV4 3NHE
• Descriptor: Histone deacetylase 6, Polyubiquitin, ZINC ION, ... (4 entities in total)
• Functional Keywords: hdac6, ubiquitin, structural genomics, structural genomics consortium, sgc, protein binding
• Biological source: Homo sapiens (human); More
• Cellular location: Nucleus: Q9UBN7
• Total number of polymer chains: 8
• Total formula weight: 83187.19

Authors

Dong, A.,Qui, W.,Ravichandran, M.,Schuetz, A.,Loppnau, P.,Li, F.,Mackenzie, F.,Kozieradzki, I.,Ouyang, H.,Structural Genomics Consortium (SGC) (deposition date: 2010-11-03, release date: 2011-02-23, Last modification date: 2023-09-06)

• Primary citation: Ouyang, H.,Ali, Y.O.,Ravichandran, M.,Dong, A.,Qiu, W.,Mackenzie, F.,Dhe-Paganon, S.,Arrowsmith, C.H.,Zhai, R.G.; Protein Aggregates Are Recruited to Aggresome by Histone Deacetylase 6 via Unanchored Ubiquitin C Termini.; J.Biol.Chem., 287:2317-2327, 2012; PubMed: 22069321; DOI: 10.1074/jbc.M111.273730

Experimental method

X-RAY DIFFRACTION (3 Å)