3OXX
Crystal Structure of HIV-1 I50V, A71V Protease in Complex with the Protease Inhibitor Atazanavir
Summary for 3OXX
Entry DOI | 10.2210/pdb3oxx/pdb |
Related | 3OXV 3OXW 3OY4 |
Descriptor | HIV-1 PROTEASE, GLYCEROL, 1,2-ETHANEDIOL, ... (7 entities in total) |
Functional Keywords | hiv-1 protease, inhibitor resistance, aids, aspartyl protease, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor |
Biological source | HIV-1 M:B_ARV2/SF2 (HIV-1) |
Cellular location | Gag-Pol polyprotein: Host cell membrane; Lipid-anchor. Matrix protein p17: Virion membrane; Lipid- anchor . Capsid protein p24: Virion . Nucleocapsid protein p7: Virion . Reverse transcriptase/ribonuclease H: Virion . Integrase: Virion : P03369 |
Total number of polymer chains | 4 |
Total formula weight | 45860.87 |
Authors | Schiffer, C.A.,Bandaranayake, R.M. (deposition date: 2010-09-22, release date: 2011-09-28, Last modification date: 2023-09-06) |
Primary citation | Mittal, S.,Bandaranayake, R.M.,King, N.M.,Prabu-Jeyabalan, M.,Nalam, M.N.,Nalivaika, E.A.,Yilmaz, N.K.,Schiffer, C.A. Structural and thermodynamic basis of amprenavir/darunavir and atazanavir resistance in HIV-1 protease with mutations at residue 50. J.Virol., 87:4176-4184, 2013 Cited by PubMed: 23365446DOI: 10.1128/JVI.03486-12 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.65 Å) |
Structure validation
Download full validation report