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3OXV

Crystal Structure of HIV-1 I50V, A71 Protease in Complex with the protease inhibitor amprenavir.

Summary for 3OXV
Entry DOI10.2210/pdb3oxv/pdb
Related3OXW 3OXX 3OY4
DescriptorHIV-1 Protease, {3-[(4-AMINO-BENZENESULFONYL)-ISOBUTYL-AMINO]-1-BENZYL-2-HYDROXY-PROPYL}-CARBAMIC ACID TETRAHYDRO-FURAN-3-YL ESTER, PHOSPHATE ION, ... (7 entities in total)
Functional Keywordshiv-1 protease, inhibitor resistance, aids, aspartyl protease, drug resistance, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
Biological sourceHIV-1 M:B_ARV2/SF2 (HIV-1)
Cellular locationGag-Pol polyprotein: Host cell membrane; Lipid-anchor. Matrix protein p17: Virion membrane; Lipid- anchor . Capsid protein p24: Virion . Nucleocapsid protein p7: Virion . Reverse transcriptase/ribonuclease H: Virion . Integrase: Virion : P03369
Total number of polymer chains4
Total formula weight45424.43
Authors
Schiffer, C.A.,Mittal, S.,Bandaranayake, R.M. (deposition date: 2010-09-22, release date: 2011-09-28, Last modification date: 2023-09-06)
Primary citationMittal, S.,Bandaranayake, R.M.,King, N.M.,Prabu-Jeyabalan, M.,Nalam, M.N.,Nalivaika, E.A.,Yilmaz, N.K.,Schiffer, C.A.
Structural and thermodynamic basis of amprenavir/darunavir and atazanavir resistance in HIV-1 protease with mutations at residue 50.
J.Virol., 87:4176-4184, 2013
Cited by
PubMed: 23365446
DOI: 10.1128/JVI.03486-12
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (1.75 Å)
Structure validation

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