3OXV
Crystal Structure of HIV-1 I50V, A71 Protease in Complex with the protease inhibitor amprenavir.
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | B, A, D, C | HIV-1 Protease | polymer | 99 | 10829.8 | 4 | UniProt (P03369) Pfam (PF00077) In PDB | HIV-1 M:B_ARV2/SF2 (HIV-1) | Retropepsin, PR |
| 2 | B, A, C | {3-[(4-AMINO-BENZENESULFONYL)-ISOBUTYL-AMINO]-1-BENZYL-2-HYDROXY-PROPYL}-CARBAMIC ACID TETRAHYDRO-FURAN-3-YL ESTER | non-polymer | 505.6 | 3 | Chemie (478) | |||
| 3 | B, C | PHOSPHATE ION | non-polymer | 95.0 | 2 | Chemie (PO4) | |||
| 4 | B, D | GLYCEROL | non-polymer | 92.1 | 2 | Chemie (GOL) | |||
| 5 | D | ACETATE ION | non-polymer | 59.0 | 2 | Chemie (ACT) | |||
| 6 | D | SULFATE ION | non-polymer | 96.1 | 1 | Chemie (SO4) | |||
| 7 | water | water | 18.0 | 179 | Chemie (HOH) |
Sequence modifications
B, A, D, C: 1 - 99 (UniProt: P03369)
| PDB | External Database | Details |
|---|---|---|
| Lys 7 | Gln 497 | engineered mutation |
| Val 50 | Ile 540 | engineered mutation |
| Ile 64 | Val 554 | conflict |
| Val 71 | Ala 561 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 43319.3 | |
| Non-Polymers* | Number of molecules | 10 |
| Total formula weight | 2105.2 | |
| All* | Total formula weight | 45424.4 |
