Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004190 | molecular_function | aspartic-type endopeptidase activity |
| A | 0006508 | biological_process | proteolysis |
| B | 0004190 | molecular_function | aspartic-type endopeptidase activity |
| B | 0006508 | biological_process | proteolysis |
| C | 0004190 | molecular_function | aspartic-type endopeptidase activity |
| C | 0006508 | biological_process | proteolysis |
| D | 0004190 | molecular_function | aspartic-type endopeptidase activity |
| D | 0006508 | biological_process | proteolysis |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 20 |
| Details | BINDING SITE FOR RESIDUE 478 B 200 |
| Chain | Residue |
| A | ASP25 |
| A | ILE84 |
| B | ASP25 |
| B | GLY27 |
| B | ALA28 |
| B | ASP30 |
| B | GLY48 |
| B | GLY49 |
| B | PRO81 |
| B | VAL82 |
| B | ILE84 |
| A | GLY27 |
| B | HOH105 |
| A | ALA28 |
| A | ASP29 |
| A | ASP30 |
| A | GLY48 |
| A | GLY49 |
| A | VAL50 |
| A | VAL82 |
| site_id | AC2 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE PO4 B 100 |
| Chain | Residue |
| A | PRO39 |
| A | GLY40 |
| B | MET36 |
| B | ASN37 |
| B | HOH114 |
| site_id | AC3 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE GOL B 101 |
| Chain | Residue |
| B | PHE53 |
| B | HOH122 |
| B | HOH127 |
| site_id | AC4 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE 478 A 200 |
| Chain | Residue |
| A | GLU35 |
| A | TRP42 |
| A | LYS55 |
| A | VAL56 |
| A | ARG57 |
| A | VAL77 |
| D | THR12 |
| D | CYS67 |
| D | GLY68 |
| site_id | AC5 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE ACT D 100 |
| site_id | AC6 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE SO4 D 101 |
| site_id | AC7 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE GOL D 102 |
| Chain | Residue |
| D | GLU21 |
| D | GLU34 |
| D | PRO81 |
| D | VAL82 |
| D | ASN83 |
| site_id | AC8 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ACT D 103 |
| Chain | Residue |
| C | PRO39 |
| C | GLY40 |
| D | MET36 |
| D | ASN37 |
| site_id | AC9 |
| Number of Residues | 21 |
| Details | BINDING SITE FOR RESIDUE 478 C 200 |
| Chain | Residue |
| C | ASP25 |
| C | GLY27 |
| C | ALA28 |
| C | ASP29 |
| C | ASP30 |
| C | VAL32 |
| C | GLY48 |
| C | GLY49 |
| C | VAL50 |
| C | ILE84 |
| C | HOH119 |
| D | ASP25 |
| D | GLY27 |
| D | ALA28 |
| D | ASP30 |
| D | VAL32 |
| D | GLY48 |
| D | GLY49 |
| D | PRO81 |
| D | VAL82 |
| D | ILE84 |
| site_id | BC1 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE PO4 C 100 |
| Chain | Residue |
| C | MET36 |
| C | ASN37 |
| C | HOH164 |
| D | PRO39 |
| D | GLY40 |
| D | HOH151 |
Functional Information from PROSITE/UniProt
| site_id | PS00141 |
| Number of Residues | 12 |
| Details | ASP_PROTEASE Eukaryotic and viral aspartyl proteases active site. ALLDTGADDTVL |
| Chain | Residue | Details |
| B | ALA22-LEU33 | |
Functional Information from SwissProt/UniProt
| Chain | Residue | Details |
| B | ASP25 | |
| A | ASP25 | |
| D | ASP25 | |
| C | ASP25 | |
| site_id | SWS_FT_FI2 |
| Number of Residues | 4 |
| Details | SITE: Cleavage; by viral protease => ECO:0000250 |
| Chain | Residue | Details |
| B | PHE99 | |
| A | PHE99 | |
| D | PHE99 | |
| C | PHE99 | |
