3OXW

Crystal Structure of HIV-1 I50V, A71V Protease in Complex with the Protease Inhibitor Darunavir

Summary for 3OXW

• Entry DOI: 10.2210/pdb3oxw/pdb
• Related: 3OXV 3OXX 3OY4
• Descriptor: HIV-1 Protease, (3R,3AS,6AR)-HEXAHYDROFURO[2,3-B]FURAN-3-YL(1S,2R)-3-[[(4-AMINOPHENYL)SULFONYL](ISOBUTYL)AMINO]-1-BENZYL-2-HYDROXYPROPYLCARBAMATE, PHOSPHATE ION, ... (7 entities in total)
• Functional Keywords: hiv-1 protease, inhibitor resistance, aids, aspartyl protease, drug resistance, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• Biological source: HIV-1 M:B_ARV2/SF2 (HIV-1)
• Cellular location: Gag-Pol polyprotein: Host cell membrane; Lipid-anchor. Matrix protein p17: Virion membrane; Lipid- anchor . Capsid protein p24: Virion . Nucleocapsid protein p7: Virion . Reverse transcriptase/ribonuclease H: Virion . Integrase: Virion : P03369
• Total number of polymer chains: 4
• Total formula weight: 45558.29

Authors

Mittal, S.,Bandaranayake, R.M.,Schiffer, C.A. (deposition date: 2010-09-22, release date: 2011-09-28, Last modification date: 2023-09-06)

• Primary citation: Mittal, S.,Bandaranayake, R.M.,King, N.M.,Prabu-Jeyabalan, M.,Nalam, M.N.,Nalivaika, E.A.,Yilmaz, N.K.,Schiffer, C.A.; Structural and thermodynamic basis of amprenavir/darunavir and atazanavir resistance in HIV-1 protease with mutations at residue 50.; J.Virol., 87:4176-4184, 2013; PubMed: 23365446; DOI: 10.1128/JVI.03486-12

Experimental method

X-RAY DIFFRACTION (1.95 Å)