Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004190 | molecular_function | aspartic-type endopeptidase activity |
| A | 0006508 | biological_process | proteolysis |
| B | 0004190 | molecular_function | aspartic-type endopeptidase activity |
| B | 0006508 | biological_process | proteolysis |
| C | 0004190 | molecular_function | aspartic-type endopeptidase activity |
| C | 0006508 | biological_process | proteolysis |
| D | 0004190 | molecular_function | aspartic-type endopeptidase activity |
| D | 0006508 | biological_process | proteolysis |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 21 |
| Details | BINDING SITE FOR RESIDUE 017 B 200 |
| Chain | Residue |
| A | ASP25 |
| B | ASP25 |
| B | GLY27 |
| B | ALA28 |
| B | ASP30 |
| B | VAL32 |
| B | GLY48 |
| B | GLY49 |
| B | VAL50 |
| B | PRO81 |
| B | ILE84 |
| A | GLY27 |
| B | HOH113 |
| B | HOH115 |
| A | ALA28 |
| A | ASP29 |
| A | ASP30 |
| A | GLY48 |
| A | GLY49 |
| A | VAL50 |
| A | VAL82 |
| site_id | AC2 |
| Number of Residues | 20 |
| Details | BINDING SITE FOR RESIDUE 017 D 200 |
| Chain | Residue |
| C | ASP25 |
| C | GLY27 |
| C | ASP29 |
| C | ASP30 |
| C | GLY48 |
| C | GLY49 |
| C | VAL50 |
| C | VAL82 |
| D | ASP25 |
| D | GLY27 |
| D | ALA28 |
| D | ASP30 |
| D | VAL32 |
| D | GLY48 |
| D | GLY49 |
| D | VAL50 |
| D | PRO81 |
| D | VAL82 |
| D | HOH104 |
| D | HOH114 |
| site_id | AC3 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE PO4 B 100 |
| Chain | Residue |
| A | ARG14 |
| A | GLY17 |
| A | HOH103 |
| B | ARG14 |
| B | ILE15 |
| B | GLY16 |
| B | GLY17 |
| B | HOH128 |
| site_id | AC4 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE PO4 A 100 |
| Chain | Residue |
| A | MET36 |
| A | ASN37 |
| B | PRO39 |
| B | GLY40 |
| site_id | AC5 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE PO4 C 100 |
| Chain | Residue |
| C | PRO39 |
| C | GLY40 |
| D | MET36 |
| D | ASN37 |
| site_id | AC6 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE ACT B 101 |
| Chain | Residue |
| B | GLY52 |
| B | PHE53 |
| B | HOH134 |
| D | THR91 |
| D | GLN92 |
| site_id | AC7 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE ACT A 101 |
| Chain | Residue |
| A | LYS7 |
| A | ARG8 |
| A | HOH111 |
| site_id | AC8 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE ACT D 100 |
| Chain | Residue |
| D | LYS20 |
| D | GLU21 |
| D | HOH113 |
| site_id | AC9 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ACT B 102 |
| Chain | Residue |
| A | TRP6 |
| B | ASN88 |
| B | THR91 |
| B | GLN92 |
| site_id | BC1 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE GOL C 101 |
| Chain | Residue |
| A | GLN61 |
| B | GLN18 |
| B | LEU19 |
| C | LYS45 |
| C | MET46 |
| site_id | BC2 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE GOL D 101 |
| Chain | Residue |
| C | GLY16 |
| C | GLY17 |
| D | ARG14 |
| D | GLY16 |
| D | GLY17 |
| D | PRO63 |
| D | HOH126 |
| site_id | BC3 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE GOL D 102 |
| Chain | Residue |
| D | THR12 |
| D | ARG14 |
| D | LEU19 |
| D | GLU65 |
| D | CYS67 |
| D | GLY68 |
| site_id | BC4 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE EDO A 102 |
| Chain | Residue |
| A | ASP29 |
| A | ARG87 |
| A | ASN88 |
| B | TRP6 |
| site_id | BC5 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE EDO B 103 |
| Chain | Residue |
| B | GLU21 |
| B | GLU34 |
| B | VAL82 |
| B | ASN83 |
| site_id | BC6 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE EDO C 102 |
| Chain | Residue |
| C | ARG8 |
| C | LEU10 |
| C | HOH106 |
| C | ILE3 |
| site_id | BC7 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE EDO C 103 |
| Chain | Residue |
| B | LYS41 |
| B | LYS43 |
| B | GLN58 |
| B | ASP60 |
| B | HOH119 |
| site_id | BC8 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE EDO C 104 |
| Chain | Residue |
| C | GLU21 |
| C | GLU34 |
| C | VAL82 |
| C | ASN83 |
| site_id | BC9 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE GOL B 104 |
| Chain | Residue |
| A | VAL50 |
| A | GLY51 |
| B | ILE54 |
| B | PRO79 |
Functional Information from PROSITE/UniProt
| site_id | PS00141 |
| Number of Residues | 12 |
| Details | ASP_PROTEASE Eukaryotic and viral aspartyl proteases active site. ALLDTGADDTVL |
| Chain | Residue | Details |
| B | ALA22-LEU33 | |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 276 |
| Details | Domain: {"description":"Peptidase A2","evidences":[{"source":"PROSITE-ProRule","id":"PRU00275","evidenceCode":"ECO:0000255"}]} |
| site_id | SWS_FT_FI2 |
| Number of Residues | 40 |
| Details | Region: {"description":"Dimerization of protease","evidences":[{"source":"UniProtKB","id":"P04585","evidenceCode":"ECO:0000250"}]} |
| site_id | SWS_FT_FI3 |
| Number of Residues | 4 |
| Details | Active site: {"description":"For protease activity; shared with dimeric partner","evidences":[{"source":"PROSITE-ProRule","id":"PRU10094","evidenceCode":"ECO:0000255"}]} |
