Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004190 | molecular_function | aspartic-type endopeptidase activity |
| A | 0006508 | biological_process | proteolysis |
| B | 0004190 | molecular_function | aspartic-type endopeptidase activity |
| B | 0006508 | biological_process | proteolysis |
| C | 0004190 | molecular_function | aspartic-type endopeptidase activity |
| C | 0006508 | biological_process | proteolysis |
| D | 0004190 | molecular_function | aspartic-type endopeptidase activity |
| D | 0006508 | biological_process | proteolysis |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE GOL B 100 |
| Chain | Residue |
| A | TRP6 |
| A | LYS7 |
| A | ARG8 |
| B | ARG87 |
| site_id | AC2 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE GOL B 101 |
| Chain | Residue |
| C | TRP6 |
| A | GLY40 |
| B | GLU35 |
| B | MET36 |
| B | ASN37 |
| C | THR4 |
| site_id | AC3 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE EDO B 102 |
| Chain | Residue |
| B | HIS69 |
| B | LYS70 |
| C | PHE53 |
| C | HOH137 |
| site_id | AC4 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE ACT B 103 |
| Chain | Residue |
| B | LYS20 |
| B | GLU21 |
| B | ASN83 |
| site_id | AC5 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE ACT B 104 |
| Chain | Residue |
| B | GLU35 |
| C | THR4 |
| C | LEU5 |
| C | TRP6 |
| D | THR91 |
| D | GLY94 |
| D | CYS95 |
| site_id | AC6 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ACT B 105 |
| Chain | Residue |
| B | GLY73 |
| B | THR74 |
| B | ASN88 |
| B | HOH133 |
| site_id | AC7 |
| Number of Residues | 18 |
| Details | BINDING SITE FOR RESIDUE DR7 A 100 |
| Chain | Residue |
| A | ARG8 |
| A | ASP25 |
| A | GLY27 |
| A | ALA28 |
| A | ASP29 |
| A | GLY48 |
| A | GLY49 |
| A | ILE84 |
| A | HOH103 |
| B | ARG8 |
| B | ASP25 |
| B | GLY27 |
| B | ALA28 |
| B | ASP29 |
| B | GLY48 |
| B | GLY49 |
| B | VAL82 |
| B | ILE84 |
| site_id | AC8 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE GOL A 101 |
| Chain | Residue |
| A | ASP29 |
| A | ARG87 |
| A | ASN88 |
| A | EDO102 |
| A | HOH136 |
| B | TRP6 |
| site_id | AC9 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE EDO A 102 |
| Chain | Residue |
| A | ARG87 |
| A | GOL101 |
| B | LYS7 |
| B | ARG8 |
| site_id | BC1 |
| Number of Residues | 19 |
| Details | BINDING SITE FOR RESIDUE DR7 C 100 |
| Chain | Residue |
| C | ARG8 |
| C | ASP25 |
| C | GLY27 |
| C | ALA28 |
| C | ASP29 |
| C | GLY48 |
| C | GLY49 |
| C | ILE84 |
| C | HOH105 |
| D | ARG8 |
| D | ASP25 |
| D | GLY27 |
| D | ALA28 |
| D | ASP29 |
| D | GLY48 |
| D | GLY49 |
| D | VAL50 |
| D | PRO81 |
| D | ILE84 |
| site_id | BC2 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE GOL C 101 |
| Chain | Residue |
| A | TRP42 |
| A | PRO44 |
| C | LEU10 |
| C | VAL11 |
| C | THR12 |
| C | CYS67 |
| C | ACT104 |
| site_id | BC3 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE GOL C 102 |
| Chain | Residue |
| A | TRP6 |
| B | GLY94 |
| B | HOH115 |
| C | VAL50 |
| C | GLY51 |
| C | HOH134 |
| D | PRO79 |
| D | PRO81 |
| site_id | BC4 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ACT C 103 |
| Chain | Residue |
| C | LYS7 |
| C | ARG8 |
| D | ARG87 |
| D | GOL100 |
| site_id | BC5 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE ACT C 104 |
| Chain | Residue |
| A | TRP42 |
| C | GOL101 |
| site_id | BC6 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE GOL D 100 |
| Chain | Residue |
| D | ARG87 |
| D | ASN88 |
| C | TRP6 |
| C | ACT103 |
| D | ASP29 |
| site_id | BC7 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE PO4 D 101 |
| Chain | Residue |
| C | PRO39 |
| C | GLY40 |
| D | MET36 |
| D | ASN37 |
| site_id | BC8 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ACT D 102 |
| Chain | Residue |
| D | GLY73 |
| D | THR74 |
| D | ASN88 |
| D | GLN92 |
| site_id | BC9 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE EDO D 103 |
| Chain | Residue |
| C | ARG87 |
| D | LYS7 |
| D | ARG8 |
Functional Information from PROSITE/UniProt
| site_id | PS00141 |
| Number of Residues | 12 |
| Details | ASP_PROTEASE Eukaryotic and viral aspartyl proteases active site. ALLDTGADDTVL |
| Chain | Residue | Details |
| B | ALA22-LEU33 | |
Functional Information from SwissProt/UniProt
| Chain | Residue | Details |
| B | ASP25 | |
| A | ASP25 | |
| C | ASP25 | |
| D | ASP25 | |
| site_id | SWS_FT_FI2 |
| Number of Residues | 4 |
| Details | SITE: Cleavage; by viral protease => ECO:0000250 |
| Chain | Residue | Details |
| B | PHE99 | |
| A | PHE99 | |
| C | PHE99 | |
| D | PHE99 | |
